PF 04671536 hydrochloride

Cat. No. 6024 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective PDE8B/8A inhibitor

化学名： 5-Methyl-3-[[(2R)-4-(2-thiazolylmethyl)-2-morpholinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 04671536 hydrochloride

PF 04671536 hydrochloride is a potent and selective PDE8B/8A inhibitor (IC₅₀ values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC₅₀ values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc

化合物库 for PF 04671536 hydrochloride

PF 04671536 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 04671536 hydrochloride

分子量	382.87
公式	C₁₄H₁₈N₈OS.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1305116-67-9
PubChem ID	131954582
InChI Key	KNBIGIZPAKPDTF-HNCPQSOCSA-N
Smiles	CC1=NC(N)=C2N=NN(C2=N1)C[C@H]3CN(CCO3)CC4=NC=CS4.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 04671536 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	7.66	20 温和加热
	DMSO	38.29	100

制备储备液 for PF 04671536 hydrochloride

以下数据基于产品分子量 382.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.06 mL	26.12 mL
5 mM	0.52 mL	2.61 mL	5.22 mL
10 mM	0.26 mL	1.31 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for PF 04671536 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 04671536 hydrochloride

参考文献是支持产品生物活性的出版物。

DeNinno et al (2012) Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg.Med.Chem.Lett. 22 5721 PMID: 22858141

If you know of a relevant reference for PF 04671536 hydrochloride, please let us know.

按标靶查看相关产品

Phosphodiesterases

按产品操作查看相关产品

查看全部 Phosphodiesterase Inhibitors

关键词: PF 04671536 hydrochloride, PF 04671536 hydrochloride supplier, PF04671536, hydrochloride, diabetes, phosphodiesterase, 8A, 8B, PDE, potent, selective, orally, bioavailable, antidiabetics, inhibitors, inhibits, Phosphodiesterases, 6024, Tocris Bioscience

篇 PF 04671536 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 PF 04671536 hydrochloride 的引用文献。您是否知道使用了 Tocris PF 04671536 hydrochloride 的优秀论文？请告知我们.