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PF 04885614

Cat. No. 4916 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective NaV1.8 channel blocker; active in vivo
化学名： 1-Methyl-1-[4-(4-trifluoromethoxy-phenyl)-1H-imidazol-2-yl]-ethylamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PF 04885614

PF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PF 04885614

PF 04885614 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 04885614

分子量 285.26
公式 C13H14F3N3O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1480833-70-2
PubChem ID 65459349
InChI Key AGORGFNWYAUYSU-UHFFFAOYSA-N
Smiles CC(C)(N)C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 04885614

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.53 100
ethanol 28.53 100

制备储备液 for PF 04885614

以下数据基于产品分子量 285.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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产品说明书 for PF 04885614

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for PF 04885614

参考文献是支持产品生物活性的出版物。

Bagal et al (2013) Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract. 4th RSC/SCI Symp. on Ion Channels as Ther. Targ

If you know of a relevant reference for PF 04885614, please let us know.

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关键词: PF 04885614, PF 04885614 supplier, PF04885614, NaV1.8, voltage, gated, sodium, channel, inhibitors, inhibits, potent, selective, in, vivo, efficacy, antinociceptive, analgesic, Voltage-gated, Sodium, Channels, 4916, Tocris Bioscience

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PF 04885614 的评论

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PF 04885614 used to understand the modulation of peripheral sensitisation.
By Alex Samuel on 01/16/2020
种属： Human

PF 04885614 as an inhibitor was used to understand the modulation of peripheral sensitisation.

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