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PF 05180999

Cat. No. 6405 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective PDE2A inhibitor
化学名： 4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PF 05180999

PF 05180999 is a potent and selective PDE2A inhibitor (IC50 = 1 nM). Exhibits 2000-fold selectivity for PDE2A over PDE10A. Brain penetrant.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PF 05180999

PF 05180999 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 05180999

分子量 414.39
公式 C19H17F3N8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1394033-54-5
PubChem ID 60143346
InChI Key CLGCHUKGBICQTE-UHFFFAOYSA-N
Smiles CC1=NC(C2=C(C3=NC=C(C(F)(F)F)C=C3)N(C)N=C2)=C4N1N=CN=C4N5CCC5

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 05180999

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.72 50
ethanol 20.72 50

制备储备液 for PF 05180999

以下数据基于产品分子量 414.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.83 mL 24.13 mL 48.26 mL
2.5 mM 0.97 mL 4.83 mL 9.65 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
25 mM 0.1 mL 0.48 mL 0.97 mL

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参考文献 for PF 05180999

参考文献是支持产品生物活性的出版物。

Mikami et al (2017) Discovery of orally bioavailable brain penetrating in vivo active phosphodiesterase 2a inhibitor series for the treatment of cognitive disorders. J.Med.Chem. 60 7658 PMID: 28759228

If you know of a relevant reference for PF 05180999, please let us know.

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关键词: PF 05180999, PF 05180999 supplier, PF05180999, potent, selective, phosphodiesterase, PDE, 2a, inhibitors, inhibits, brain, penetrant, Phosphodiesterases, 6405, Tocris Bioscience

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