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Submit ReviewPF 06273340
说明： Potent and selective pan-Trk inhibitor; peripherally restricted
化学名： N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide
纯度： ≥98% (HPLC)
生物活性 for PF 06273340
PF 06273340 is a potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for PF 06273340
PF 06273340 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for PF 06273340
| 分子量 | 479.93 |
| 公式 | C23H22ClN7O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1402438-74-7 |
| PubChem ID | 66571548 |
| InChI Key | BPIWZDNVMQQBQX-UHFFFAOYSA-N |
| Smiles | NC1=NC=C2C(N(C(C)(C)CO)C=C2C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PF 06273340
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 47.99 | 100 |
制备储备液 for PF 06273340
以下数据基于产品分子量 479.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.08 mL | 10.42 mL | 20.84 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.17 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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产品说明书 for PF 06273340
参考文献 for PF 06273340
参考文献是支持产品生物活性的出版物。
Skerratt et al (2016) The discovery of a potent, selective, and peripherally restricted pan-Trk inhibitor (PF-06273340) for the treatment of pain. J.Med.Chem. 59 10084 PMID: 27766865
If you know of a relevant reference for PF 06273340, please let us know.
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关键词: PF 06273340, PF 06273340 supplier, PF06273340, Trk, A, B, C, tropomyosin-related, kinase, receptors, neurotrophins, inhibitors, inhibits, peripherally, restricted, potent, selective, Receptors, 6115, Tocris Bioscience
1 篇 PF 06273340 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PF 06273340 的部分引用包括：
Jeongwu et al (2018) Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma. Cancer Res 78 4360-4369 PMID: 29844123
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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