PHA 767491 hydrochloride

Cat. No. 3140 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cdk inhibitor; potently inhibits cdk9; also inhibits MK2

化学名： 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride

纯度： ≥99% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PHA 767491 hydrochloride

PHA 767491 hydrochloride is an ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.034 - 0.75, 0.24 - 1.2, 0.25 - 1.1 and 0.46 - 1 μM for cdk9, cdk2, cdk1 and cdk5, respectively). Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2; IC₅₀ = 171 nM). Prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo.

化合物库 for PHA 767491 hydrochloride

PHA 767491 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PHA 767491 hydrochloride

分子量	249.7
公式	C₁₂H₁₁N₃O.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	942425-68-5
PubChem ID	11715766
InChI Key	IMVNFURYBZMFDZ-UHFFFAOYSA-N
Smiles	O=C1NCCC2=C1C=C(C3=CC=NC=C3)N2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PHA 767491 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	24.97	100
	DMSO	24.97	100

制备储备液 for PHA 767491 hydrochloride

以下数据基于产品分子量 249.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4 mL	20.02 mL	40.05 mL
5 mM	0.8 mL	4 mL	8.01 mL
10 mM	0.4 mL	2 mL	4 mL
50 mM	0.08 mL	0.4 mL	0.8 mL

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产品说明书 for PHA 767491 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PHA 767491 hydrochloride

参考文献是支持产品生物活性的出版物。

Anderson et al (2007) Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J.Med.Chem. 50 2647 PMID: 17480064

Jackson (2008) Stopping replication, at the beginning. Nature Chem.Biol. 4 331 PMID: 18488006

Montagnoli et al (2008) A cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumour activity. Nature Chem.Biol. 4 357 PMID: 18469809

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for PHA 767491 hydrochloride, please let us know.

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