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Submit ReviewPhaclofen
说明： Selective GABAB antagonist
化学名： (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid
纯度： ≥97% (HPLC)
生物活性 for Phaclofen
Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).
技术数据 for Phaclofen
| 分子量 | 249.63 |
| 公式 | C9H13ClNO3P |
| 储存 | Store at RT |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 114012-12-3 |
| PubChem ID | 1641 |
| InChI Key | VSGNGLJPOGUDON-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(CN)CP(O)(O)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Phaclofen
参考文献 for Phaclofen
参考文献是支持产品生物活性的出版物。
Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of bac. induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77 PMID: 3362432
Karlsson et al (1988) Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485 PMID: 2838310
Kerr et al (1987) Phaclofen: a peripheral and central bac. antagonist. Brain Res. 405 150 PMID: 3032346
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关键词: Phaclofen, Phaclofen supplier, selective, GABAB, antagonists, Receptors, 0178, Tocris Bioscience
3 篇 Phaclofen 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Phaclofen 的部分引用包括：
Dulcis et al (2017) Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference. Neuron 95 1319 PMID: 28867550
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol 131 1050 PMID: 11082110
Ibbotson et al (1997) Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro. Br J Pharmacol 122 956 PMID: 9384515
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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