主页 / 药理学 / Ion Channels / Transient Receptor Potential Channels / TRPP Channels / TRPP Channel Blockers / Phenamil

Phenamil

Cat. No. 3379 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels
化学名： 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Phenamil

Phenamil is a TRPP3 channel inhibitor (IC50 = 0.14 μM). Also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Derivative of amiloride (Cat. No. 0890).

化合物库 for Phenamil

Phenamil is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Phenamil

分子量 401.83
公式 C12H12ClN7O.CH3SO3H
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1161-94-0
PubChem ID 9604979
InChI Key MHPIZTURFVSLTJ-UHFFFAOYSA-N
Smiles NC1=C(Cl)N=C(C(NC(NC2=CC=CC=C2)=N)=O)C(N)=N1.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Phenamil

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.18 100

制备储备液 for Phenamil

以下数据基于产品分子量 401.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Phenamil

参考文献是支持产品生物活性的出版物。

Barbry et al (1989) Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels. Biochemistry. 28 3744 PMID: 2546581

Dai et al (2007) Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601

If you know of a relevant reference for Phenamil, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 TRPP Channel Blockers

关键词: Phenamil, Phenamil supplier, TRPP3, TRP, antagonists, sodium, channels, blocker, amiloride, Na, epithelial, Epithelial, Sodium, Channels, TRPP, 3379, Tocris Bioscience

篇 Phenamil 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Phenamil 的引用文献。 您是否知道使用了 Tocris Phenamil 的优秀论文？ 请告知我们.

Phenamil 的评论

目前没有该产品的评论。 Be the first to review Phenamil and earn rewards!

Have you used Phenamil?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review