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PhiKan 083

Cat. No. 4326 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4326 has been discontinued.

View all p53 products.
说明： p53 stabilizing agent
化学名： 9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for PhiKan 083

PhiKan 083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.

化合物库 for PhiKan 083

PhiKan 083 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PhiKan 083

分子量 274.79
公式 C16H18N2.HCl
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1050480-30-2
PubChem ID 16255105
InChI Key IXWVUPURFWFRNE-UHFFFAOYSA-N
Smiles CCN1C3=C(C=CC=C3)C2=C1C=CC(CNC)=C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PhiKan 083

参考文献是支持产品生物活性的出版物。

Boeckler et al (2008) Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 105 10360 PMID: 18650397

Wiman (2010) Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 29 4245 PMID: 20498645

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关键词: PhiKan 083, PhiKan 083 supplier, PhiKan083, supplier, p53, stabilizing, stabilising, stabiliser, agent, transcription, factors, Y220C, mutation, thermostability, 4326, Tocris Bioscience

1 篇 PhiKan 083 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PhiKan 083 的部分引用包括：

Soares et al (2016) Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule. Oncotarget 7 4326 PMID: 26735173

PhiKan 083 的评论

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for PhiKan 083

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.