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PHM 27 (human)

Cat. No. 2080 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent calcitonin agonist; endogenous analog of human VIP
别名： Peptide histidine methionine 27 (human),Human PHI 27
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生物活性 技术数据 说明书 参考文献

生物活性 for PHM 27 (human)

PHM 27 (human) is an endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.

技术数据 for PHM 27 (human)

分子量 2985.44
公式 C135H214N34O40S
序列 HADGVFTSDFSKLLGQLSAKKYLESLM

(Modifications: Met-27 = C-terminal amide)
储存 Desiccate at -20°C
CAS Number 87403-73-4
PubChem ID 16133840
InChI Key YLBIOQUUAYXLJJ-WZUUGAJWSA-N
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PHM 27 (human)

参考文献是支持产品生物活性的出版物。

Itoh et al (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304 547 PMID: 6571696

Kato et al (1994) Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells. J.Biol.Chem. 269 21223 PMID: 8063743

Ma et al (2004) Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem.Pharmacol. 67 1279 PMID: 15013843

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关键词: PHM 27 (human), PHM 27 (human) supplier, Potent, calcitonin, receptor, agonists, endogenous, human, VIP, prepro-VIP, analogue, porcine, PHI27, Receptors, Vasoactive, intestinal, peptide, PHM27, (human), Peptide, histidine, methionine27, 118025-43-7, methionine, 27, Human, PHI, Calcitonin, and, Related, 2080, Tocris Bioscience

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