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Piclamilast

Cat. No. 4525 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective PDE4 inhibitor
别名： RP 73401
化学名： 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Piclamilast

Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM).

化合物库 for Piclamilast

Piclamilast is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Piclamilast

分子量 381.25
公式 C18H18Cl2N2O3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 144035-83-6
PubChem ID 154575
InChI Key RRRUXBQSQLKHEL-UHFFFAOYSA-N
Smiles O=C(NC3=C(Cl)C=NC=C3Cl)C1=CC(OC2CCCC2)=C(OC)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Piclamilast

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.12 100

制备储备液 for Piclamilast

以下数据基于产品分子量 381.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.11 mL 26.23 mL
5 mM 0.52 mL 2.62 mL 5.25 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for Piclamilast

参考文献是支持产品生物活性的出版物。

Raeburn et al (1994) Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor. Br.J.Pharmacol. 113 1423 PMID: 7889300

Hatzelmann and Schudt (2001) Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflum. in vitro. J.Pharmacol.Exp.Ther. 297 267 PMID: 11259554

Zhao et al (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. J.Pharmacol.Exp.Ther. 305 565 PMID: 12704225

If you know of a relevant reference for Piclamilast, please let us know.

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关键词: Piclamilast, Piclamilast supplier, RP73401, phosphodiesterases, pde4, potent, selective, inhibitors, inhibits, RP, 73401, Phosphodiesterases, 4525, Tocris Bioscience

1 篇 Piclamilast 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Piclamilast 的部分引用包括：

Zhang et al (2019) PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. Sci Adv 5 eaaw5870 PMID: 31131329

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