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Submit ReviewPimozide
说明： D2-like antagonist; also high affinity 5-HT7 antagonist
化学名： 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
纯度： ≥98% (HPLC)
生物活性 for Pimozide
Pimozide is a dopamine D2-receptor antagonist and antipsychotic which binds with very high affinity to the cloned rat 5-HT7 receptor (Ki = 0.5 nM).
化合物库 for Pimozide
Pimozide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Pimozide
| 分子量 | 461.55 |
| 公式 | C28H29F2N3O |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2062-78-4 |
| PubChem ID | 16362 |
| InChI Key | YVUQSNJEYSNKRX-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(C=C1)C(CCCN1CCC(CC1)N1C(=O)NC2=CC=CC=C12)C1=CC=C(F)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Pimozide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 9.23 | 20 |
制备储备液 for Pimozide
以下数据基于产品分子量 461.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.83 mL | 54.17 mL | 108.33 mL |
| 1 mM | 2.17 mL | 10.83 mL | 21.67 mL |
| 2 mM | 1.08 mL | 5.42 mL | 10.83 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.17 mL |
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产品说明书 for Pimozide
参考文献 for Pimozide
参考文献是支持产品生物活性的出版物。
Roth et al (1994) Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J.Pharmacol.Exp.Ther. 268 1403 PMID: 7908055
Merck Index 12 7589
If you know of a relevant reference for Pimozide, please let us know.
按产品操作查看相关产品
关键词: Pimozide, Pimozide supplier, D2-like, antagonists, High, affinity, 5-HT7, D2, Dopamine, Non-Selective, Receptors, Serotonin, 5-Hydroxytryptamine, dopaminergic, Non-selective, 0937, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Pimozide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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Pimozide 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.