Pioglitazone hydrochloride

Name: Pioglitazone hydrochloride
Brand: Tocris Bioscience
SKU: 4124
Rating: 5 (1 reviews)

Cat. No. 4124 6 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective PPARγ agonist; antidiabetic agent

化学名： 5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Pioglitazone hydrochloride

Pioglitazone hydrochloride is a selective PPARγ agonist (EC₅₀ = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity. Also enhances proliferation and survival of mESCs and acts synergistically with Y-27632 (Cat. No. 1254) to improve survival of dissociated single hPSCs and increase colony formation.

化合物库 for Pioglitazone hydrochloride

Pioglitazone hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Pioglitazone hydrochloride

分子量	392.9
公式	C₁₉H₂₀N₂O₃S.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	112529-15-4
PubChem ID	60560
InChI Key	GHUUBYQTCDQWRA-UHFFFAOYSA-N
Smiles	O=C(S3)NC(C3CC(C=C2)=CC=C2OCCC1=NC=C(CC)C=C1)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pioglitazone hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	9.82	25

制备储备液 for Pioglitazone hydrochloride

以下数据基于产品分子量 392.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	10.18 mL	50.9 mL	101.81 mL
1.25 mM	2.04 mL	10.18 mL	20.36 mL
2.5 mM	1.02 mL	5.09 mL	10.18 mL
12.5 mM	0.2 mL	1.02 mL	2.04 mL

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产品说明书 for Pioglitazone hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Pioglitazone hydrochloride

参考文献是支持产品生物活性的出版物。

Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907

Sakamoto et al (2000) Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglit. Biochem.Biophys.Res.Commun. 278 704 PMID: 11095972

Momose et al (2002) Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as Ins sensitizers with antidiabetic activities. J.Med.Chem. 45 1518 PMID: 11906293

Kajabadi et al (2015) The synergistic enhancement of cloning efficiency in individualized human pluripotent stem cells by peroxisome proliferative-activated receptor-γ (PPARγ) activation and Rho-associated kinase (ROCK) inhibition. J.Biol.Chem. 290 26303 PMID: 26336103

If you know of a relevant reference for Pioglitazone hydrochloride, please let us know.

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关键词: Pioglitazone hydrochloride, Pioglitazone hydrochloride supplier, PPARg, PPARgamma, PPARγ, peroxisome, proliferator, activated, receptors, nuclear, agonists, antidiabetic, agents, stem, cell, dissociation, cloning, effciency, Receptors, Stem, Cell, Proliferation, 4124, Tocris Bioscience

6 篇 Pioglitazone hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pioglitazone hydrochloride 的部分引用包括：

Eunji et al (2023) Inhibition of neuronal peroxisome proliferator-activated receptor-γ attenuates motor function improvement after spinal cord injury in rats. Eur J Neurosci 57 1466-1480 PMID: 36970752

Helmy et al (2015) Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs. PLoS One 10 e0142303 PMID: 26536032

Thakran et al (2015) Pioglit restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. PLoS One 56 177 PMID: 25525174

Wahlang et al (2014) Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140 283 PMID: 24812009

Merkulova et al (2019) Ponatinib treatment promotes arterial thrombosis and hyperactive platelets. Blood Adv 3 2312 PMID: 31383636

Byrne et al (2015) Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. J Diabetes Res 2015 752481 PMID: 25759824

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