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Submit ReviewPIT 1
说明： PIP3 antagonist. Blocks PIP3-PH interaction; inhibits Akt signaling
化学名： N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
纯度： ≥99% (HPLC)
生物活性 for PIT 1
PIT 1 is a selective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo.
技术数据 for PIT 1
| 分子量 | 351.76 |
| 公式 | C14H10ClN3O4S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 53501-41-0 |
| PubChem ID | 3664359 |
| InChI Key | RIGXBXPAOGDDIG-UHFFFAOYSA-N |
| Smiles | ClC1=C(O)C(NC(NC(C2=CC=CC=C2)=O)=S)=CC([N+]([O-])=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PIT 1
参考文献 for PIT 1
参考文献是支持产品生物活性的出版物。
Miao et al (2010) Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc.Natl.Acad.Sci. 107 2012
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关键词: PIT 1, PIT 1 supplier, PIT1, Supplier, Akt, signaling, inhibitors, inhibits, blocks, PH-PIP3, pleckstrin, homology, PITenins, Inositol, Lipids, Protein, Kinase, B/Akt, 4168, Tocris Bioscience
1 篇 PIT 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PIT 1 的部分引用包括：
Juvekar et al (2016) Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proc Natl Acad Sci U S A 113 E4338 PMID: 27402769
PIT 1 的评论
平均评分: 5 (Based on 1 Review.)
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Works well.
By
Anonymous on 05/05/2020
分析类型： In Vitro
种属： Human
细胞系/组织： HCC1937
Induction of PAR and gamma H2ax by the PIP3-mimetic PIT1 (0-100uM)
