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PK-THPP

Cat. No. 5338 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent K2P9.1 (TASK-3) channel blocker
化学名： 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PK-THPP

PK-THPP is a potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.

化合物库 for PK-THPP

PK-THPP is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PK-THPP

分子量 468.59
公式 C29H32N4O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1332454-07-5
PubChem ID 53464059
InChI Key CJZGRIRZVHNUSM-UHFFFAOYSA-N
Smiles O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N(C3)CCC4=C3C(N5CCC(C(CCC)=O)CC5)=NC=N4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PK-THPP

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.43 50
1eq. HCl 9.37 20 温和加热

制备储备液 for PK-THPP

以下数据基于产品分子量 468.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.27 mL 21.34 mL 42.68 mL
2.5 mM 0.85 mL 4.27 mL 8.54 mL
5 mM 0.43 mL 2.13 mL 4.27 mL
25 mM 0.09 mL 0.43 mL 0.85 mL

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参考文献 for PK-THPP

参考文献是支持产品生物活性的出版物。

Cotten (2013) TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth.Analg. 116 810 PMID: 23460565

Coburn et al (2012) Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem 7 123 PMID: 21916012

If you know of a relevant reference for PK-THPP, please let us know.

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关键词: PK-THPP, PK-THPP supplier, potent, TASK3, channels, blockers, TWIK, related, acid, sensitive, K+, two, pore, potassium, K2P9.1, subfamily, member, 9, Two-P, Potassium, Channels, 5338, Tocris Bioscience

1 篇 PK-THPP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PK-THPP 的部分引用包括：

Veldkamp et al (2018) Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel. Nat Commun 9 4357 PMID: 30341287

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PK-THPP 的评论

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PH-THPP exhibits concentration dependent blocking activity.
By Eleanor Baxter on 10/29/2018
分析类型： In Vitro
种属： Human

A very potent K2p channel blocker which was used to figure out the blocking activity as concentration of the blocker molecule increased. PK-THPP is a great antagonist molecule which shows channel obstructing properties which is concentration dependent.

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