PLpro inhibitor 19

Cat. No. 7505 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： SARS-CoV-2 PLpro and replication inhibitor

化学名： (R)-N-(3-Fluoro-5-((1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxamido)methyl)phenyl)-4-methylpiperazine-1-carboxamide

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PLpro inhibitor 19

PLpro inhibitor 19 is a SARS-CoV-2 inhibitor that inhibits viral replication and PLpro enzymatic activity in vitro (IC₅₀ values are 0.18 μM and 0.44 μM respectively). PLpro inhibitor 19 is selective for PLpro over human deubiquitinating enzymes (DUBs) and DUB-like proteases and displays no cytotoxicity at up to 10 μM.

技术数据 for PLpro inhibitor 19

分子量	531.68
公式	C₃₁H₃₈FN₅O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2863607-73-0
PubChem ID	155925847
InChI Key	ZGUISYSWQQIAHK-JOCHJYFZSA-N
Smiles	CN1CCN(CC1)C(NC2=CC(F)=CC(CNC(C3CCN(CC3)[C@@H](C4=C5C=CC=CC5=CC=C4)C)=O)=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PLpro inhibitor 19

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	53.17	100
	ethanol	53.17	100

制备储备液 for PLpro inhibitor 19

以下数据基于产品分子量 531.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.88 mL	9.4 mL	18.81 mL
5 mM	0.38 mL	1.88 mL	3.76 mL
10 mM	0.19 mL	0.94 mL	1.88 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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产品说明书 for PLpro inhibitor 19

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PLpro inhibitor 19

参考文献是支持产品生物活性的出版物。

Shan et al (2021) Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem.Biol. 28 855 PMID: 33979649

If you know of a relevant reference for PLpro inhibitor 19, please let us know.

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