PLpro inhibitor 6

Cat. No. 7357 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： SARS-CoV and SARS-CoV-2 PLpro inhibitor

化学名： 5-(Acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PLpro inhibitor 6

PLpro inhibitor 6 is a SARS-CoV and SAR-CoV-2 PLpro inhibitor (IC₅₀ values are 2.6 and 5.0 μM, respectively). Inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC₅₀ values are 13.1 and 21 μM, respectively).

技术数据 for PLpro inhibitor 6

分子量	346.43
公式	C₂₂H₂₂N₂O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1093070-14-4
PubChem ID	44235889
InChI Key	KGPYBLOBHQLIET-OAHLLOKOSA-N
Smiles	C[C@H](C1=CC=CC2=C1C=CC=C2)NC(C3=C(C=CC(NC(C)=O)=C3)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PLpro inhibitor 6

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	34.64	100
	ethanol	6.93	20

制备储备液 for PLpro inhibitor 6

以下数据基于产品分子量 346.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.43 mL	28.87 mL
5 mM	0.58 mL	2.89 mL	5.77 mL
10 mM	0.29 mL	1.44 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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产品说明书 for PLpro inhibitor 6

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PLpro inhibitor 6

参考文献是支持产品生物活性的出版物。

Freitas et al (2020) Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease. ACS Infect.Dis. 6 2099 PMID: 32428392

Ratia et al (2008) A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc.Natl.Acad.Sci.U.S.A. 105 16119 PMID: 18852458

If you know of a relevant reference for PLpro inhibitor 6, please let us know.

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