(+)-Clopidogrel hydrogen sulfate

Cat. No. 1820 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective P2Y₁₂ antagonist

别名： Plavix

化学名： (S)-(+)-Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrogen sulfate

纯度： ≥99% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (+)-Clopidogrel hydrogen sulfate

(+)-Clopidogrel hydrogen sulfate is a selective, high affinity P2Y₁₂ receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity. Active enantiomer of (±)-clopidogrel hydrochloride (Cat. No. 2490). Requires bioactivation.

技术数据 for (+)-Clopidogrel hydrogen sulfate

分子量	419.9
公式	C₁₆H₁₆ClNO₂S.H₂SO₄
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	120202-66-6
PubChem ID	115366
InChI Key	FDEODCTUSIWGLK-RSAXXLAASA-N
Smiles	OS(O)(=O)=O.COC(=O)[C@@H](N1CCC2=C(C1)C=CS2)C1=CC=CC=C1Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (+)-Clopidogrel hydrogen sulfate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	41.99	100
	DMSO	41.99	100

制备储备液 for (+)-Clopidogrel hydrogen sulfate

以下数据基于产品分子量 419.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.91 mL	23.82 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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产品说明书 for (+)-Clopidogrel hydrogen sulfate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (+)-Clopidogrel hydrogen sulfate

参考文献是支持产品生物活性的出版物。

Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449

Reist et al (2000) Very low chiral inversion of clopid. in rats: a pharmacokinetic and mechanistic investigation. Drug Metab.Disp. 28 1405

Savi et al (2001) P2Y12, a new platelet ADP receptor, target of clopid. Biochem.Biophys.Res.Comm. 283 379

Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y₁₂ adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174

If you know of a relevant reference for (+)-Clopidogrel hydrogen sulfate, please let us know.

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Purinergic (P2Y) Receptors

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