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(±)-Clopidogrel hydrochloride

Cat. No. 2490 1 Review Submit a Review Datasheet / COA / SDS
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Description: Selective P2Y12 antagonist
Alternative Names: Plavix
Chemical Name: Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for (±)-Clopidogrel hydrochloride

(±)-Clopidogrel hydrochloride is a selective, high affinity P2Y12 receptor antagonist (pKi = 6.9 for hP2Y12 receptor). Inhibits ADP-induced platelet aggregation; potent antithrombotic agent. Requires bioactivation, unlike PSB 0739.

Active Enantiomer also available.

Technical Data for (±)-Clopidogrel hydrochloride

M. Wt 358.28
Formula C16H16NO2SCl.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 130209-90-4
PubChem ID 22386150
InChI Key XIHVAFJSGWDBGA-UHFFFAOYSA-N
Smiles Cl.COC(=O)C(N1CCC2=C(C1)C=CS2)C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-Clopidogrel hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.83 100
ethanol 35.83 100

Preparing Stock Solutions for (±)-Clopidogrel hydrochloride

The following data is based on the product molecular weight 358.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.96 mL 27.91 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets for (±)-Clopidogrel hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for (±)-Clopidogrel hydrochloride

References are publications that support the biological activity of the product.

Kugelgen (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 110 415 PMID: 16257449

Savi et al (2001) P2Y12, a new platelet ADP receptor, target of clopid. Biochem.Biophys.Res.Comm. 283 379

Savi and Herbert (2005) Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas. 31 174

If you know of a relevant reference for (±)-Clopidogrel hydrochloride, please let us know.

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Keywords: (±)-Clopidogrel hydrochloride, (±)-Clopidogrel hydrochloride supplier, Selective, P2Y12, antagonists, Receptors, Purinergic, purinoceptors, p2yt, antagonises, inhibitors, inhibits, Plavix, P2Y, 2490, Tocris Bioscience

Citations for (±)-Clopidogrel hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for (±)-Clopidogrel hydrochloride. Do you know of a great paper that uses (±)-Clopidogrel hydrochloride from Tocris? Please let us know.

Reviews for (±)-Clopidogrel hydrochloride

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P2Y12 antagonist.
By Anonymous on 09/20/2018
Species: Human

incubation and during assay

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.