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Submit Review(+)-Fluprostenol
说明： High affinity FP prostaglandin receptor agonist
别名： Travoprost acid
化学名： (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid
纯度： ≥95% (HPLC)
生物活性 for (+)-Fluprostenol
(+)-Fluprostenol is a prostaglandin F2α (FP) receptor agonist (Ki = 49.9 nM; EC50 = 2.4 nM). Stimulates intracellular calcium mobilization in cloned human ocular FP receptors, rat A7r5 cells and mouse 3T3 cells (EC50 values are 17.5, 19.1 and 37.3 nM respectively). Analog of prostaglandin F2α. Isopropyl ester travaprost (Cat. No. 4218) also available.
技术数据 for (+)-Fluprostenol
| 分子量 | 458.47 |
| 公式 | C23H29F3O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 54276-17-4 |
| PubChem ID | 5311100 |
| InChI Key | WWSWYXNVCBLWNZ-QIZQQNKQSA-N |
| Smiles | O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (+)-Fluprostenol
参考文献 for (+)-Fluprostenol
参考文献是支持产品生物活性的出版物。
Kelly et al (2003) Real-time intracellular Ca2+ mobilization by travo. acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat and cloned human FP prostaglandin receptors. J.Pharmacol.Exp.Ther. 304 238 PMID: 12490597
Sharif et al (2003) Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other EP prostaglandin receptor agonist analogues. Invest.Ophthalmol.Vis.Sci. 44 715 PMID: 12556403
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关键词: (+)-Fluprostenol, (+)-Fluprostenol supplier, Travoprost, acid, prostaglandin, F2alpha, F2a, F2α, receptors, agonists, Prostanoid, Receptors, 4542, Tocris Bioscience
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