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Submit Review(+)-MK 801 maleate
说明： Non-competitive NMDA antagonist; acts at ion channel site
别名： Dizocilpine
化学名： (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate
纯度： ≥99% (HPLC)
生物活性 for (+)-MK 801 maleate
(+)-MK 801 maleate is a high affinity (Ki = 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. It is an effective anti-ischemic agent in several animal models. (+)-MK 801 maleate increases motor activity in rat models. (+)-MK 801 maleate inhibits proliferation and increases apoptosis in hippocampal neural stem cells (NSCs). (+)-MK 801 maleate induces schizophrenia-like symptoms in rodents.
(-)-enantiomer also available.
化合物库 for (+)-MK 801 maleate
(+)-MK 801 maleate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for (+)-MK 801 maleate
| 分子量 | 337.37 |
| 公式 | C16H15N.C4H4O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 77086-22-7 |
| PubChem ID | 6420042 |
| InChI Key | QLTXKCWMEZIHBJ-PJGJYSAQSA-N |
| Smiles | O=C(O)/C=C\C(O)=O.C[C@]1(N4)C3=C(C=CC=C3)C[C@@H]4C2=C1C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (+)-MK 801 maleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 3.37 | 10 温和加热 | |
| DMSO | 33.74 | 100 |
制备储备液 for (+)-MK 801 maleate
以下数据基于产品分子量 337.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.82 mL | 29.64 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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产品说明书 for (+)-MK 801 maleate
参考文献 for (+)-MK 801 maleate
参考文献是支持产品生物活性的出版物。
Gill et al (1991) The neuroprotective action of dizocilpine (MK-801) in the rat middle cerebral artery occlusion model of focal ischaemia. Br.J.Pharmacol. 103 2030 PMID: 1912992
Hatfield et al (1992) The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model. Eur.J.Pharmacol. 216 1 PMID: 1526248
Wong et al (1986) The anticonvulsant MK 801 is a potent N-MthD.-aspartate antagonist. Proc.Natl.Acad.Sci.U.S.A. 83 7104 PMID: 3529096
Zajaczkowski et al (1997) Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 36 961 PMID: 9257940
Carey et al (1998) Effects of dizocilpine (MK-801) on motor activity and memory. Psychopharmacology 137 241 PMID: 9683001
Ding et al (2018) Effect of NMDA on proliferation and apoptosis in hippocampal neural stem cells treated with MK-801. Exp.Ther.Med. 16 1137 PMID: 30116364
If you know of a relevant reference for (+)-MK 801 maleate, please let us know.
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关键词: (+)-MK 801 maleate, (+)-MK 801 maleate supplier, Non-competitive, NMDA, antagonists, ion, channel, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, (+)-MK801, maleate, MK801, apoptotic, apoptosis, antiproliferative, Dizocilpine, 0924, Tocris Bioscience
91 篇 (+)-MK 801 maleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (+)-MK 801 maleate 的部分引用包括：
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Anonymous on 04/04/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： Sprague-Dawley rats primary neuronal
10 μM MK-801 for 10 min
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