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Submit Review(+)-UH 232 maleate
说明： D2 autoreceptor antagonist. Also D3 partial agonist
化学名： cis-(+)-5-Methoxy-1-methyl-2-(di-N-propylamino)tetralin maleate
生物活性 for (+)-UH 232 maleate
(+)-UH 232 maleate is a D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay); displays preferential activity at central dopamine autoreceptors. Stimulates a marked acceleration of dopamine synthesis and turnover. Produces locomotor stimulation. Exhibits little or no activity at central noradrenalin and 5-HT receptors. Also D3 partial agonist.
技术数据 for (+)-UH 232 maleate
| 分子量 | 391.51 |
| 公式 | C18H29NO.C4H4O4 |
| 储存 | Store at RT |
| CAS Number | 1217473-50-1 |
| PubChem ID | 46830250 |
| InChI Key | MEQAJDYHKYAPJE-GUUGRXDUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.CCCN(CCC)[C@@H]1CCC2=C(C=CC=C2OC)[C@@H]1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (+)-UH 232 maleate
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参考文献 for (+)-UH 232 maleate
参考文献是支持产品生物活性的出版物。
Griffon et al (1995) The preferential DA D3 receptor ligand, (+)-UH 232, is a partial agonist. Eur.J.Pharmacol. 282 R3 PMID: 7498261
Hall and Strange (1997) Evidence that antipsychotic drugs are inverse agonists at D2 DA receptors. Br. J. Pharmacol. 121 731 PMID: 9208141
Johansson et al (1985) Novel DA receptor agonists and antagonists with preferential action on autoreceptors. J.Med.Chem. 28 1049 PMID: 3927002
Svensson et al (1986) (+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential DA autoreceptor antagonists. Naunyn Schmiedebergs Arch.Pharmacol. 334 234 PMID: 2880302
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.