PMPA (NAALADase inhibitor)

Cat. No. 1380 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： GCP II inhibitor

化学名： 2-(Phosphonomethyl)pentane-1,5-dioic acid

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PMPA (NAALADase inhibitor)

PMPA (NAALADase inhibitor) is a highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a K_i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

许可信息

Sold with the permission of AstraZeneca Ltd.

技术数据 for PMPA (NAALADase inhibitor)

分子量	226.12
公式	C₆H₁₁O₇P
储存	Desiccate at RT
CAS Number	173039-10-6
PubChem ID	10130754
InChI Key	ISEYJGQFXSTPMQ-UHFFFAOYSA-N
Smiles	OC(=O)CCC(CP(=O)(O)O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PMPA (NAALADase inhibitor)

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	22.61	100

制备储备液 for PMPA (NAALADase inhibitor)

以下数据基于产品分子量 226.12。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.42 mL	22.11 mL	44.22 mL
5 mM	0.88 mL	4.42 mL	8.84 mL
10 mM	0.44 mL	2.21 mL	4.42 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

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产品说明书 for PMPA (NAALADase inhibitor)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PMPA (NAALADase inhibitor)

参考文献是支持产品生物活性的出版物。

Jackson et al (1996) Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 39 619 PMID: 8558536

Slusher et al (1999) Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 5 1396 PMID: 10581082

Thomas et al (2003) NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 471 177 PMID: 12826236

Rahn et al (2012) Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proc.Natl.Acad.Sci.U S A (Epub ahead of print] PMID: 23169655

If you know of a relevant reference for PMPA (NAALADase inhibitor), please let us know.

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关键词: PMPA (NAALADase inhibitor), PMPA (NAALADase inhibitor) supplier, potent, selective, NAALADase, GCP, II, inhibitors, inhibits, Carboxypeptidase, NAAG, Peptidase, Proteinases, Proteases, AstraZeneca, Miscellaneous, Glutamate, 1380, Tocris Bioscience

1 篇 PMPA (NAALADase inhibitor) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PMPA (NAALADase inhibitor) 的部分引用包括：

Schottelius et al (2019) Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer. J Nucl Med 60 71 PMID: 30237214

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