主页 / 药理学 / Ion Channels / Transient Receptor Potential Channels / TRPA1 / TRPA1 Activators / Polygodial

Polygodial

Cat. No. 3197 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： TRPA1 channel activator; analgesic and antifungal
化学名： (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
纯度： ≥97% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Polygodial

Polygodial is a TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.

化合物库 for Polygodial

Polygodial is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Polygodial

分子量 234.33
公式 C15H22O2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 6754-20-7
PubChem ID 72503
InChI Key AZJUJOFIHHNCSV-KCQAQPDRSA-N
Smiles [H][C@]12C(C)(C)CCC[C@@](C)1[C@@H](C=O)C(C=O)=CC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Polygodial

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.43 100
ethanol 23.43 100

制备储备液 for Polygodial

以下数据基于产品分子量 234.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.67 mL
5 mM 0.85 mL 4.27 mL 8.53 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for Polygodial

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Polygodial

参考文献是支持产品生物活性的出版物。

Lunde and Kubo (2000) Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 44 1943 PMID: 10858359

Escalera et al (2008) TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J.Biol.Chem. 283 24136 PMID: 18550530

Matsuda et al (2002) Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg.Med.Chem.Letts. 12 477 PMID: 11814823

If you know of a relevant reference for Polygodial, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 TRPA1 Activators

关键词: Polygodial, Polygodial supplier, TRPA1, channel, activator, mitochondrial, ATPase, antifungal, inhibits, Other, ATPases, Antifungals, 3197, Tocris Bioscience

2 篇 Polygodial 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Polygodial 的部分引用包括：

Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Mol Cancer 21 4852 PMID: 25944998

Silverman et al (2023) Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1 beta induced hypothermia and reflex anti-inflammatory responses. Mol Med 29 4 PMID: 36650454

您是否知道使用了 Tocris Polygodial 的优秀论文？ 请告知我们.

Polygodial 的评论

目前没有该产品的评论。 Be the first to review Polygodial and earn rewards!

Have you used Polygodial?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review