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Pomalidomide 4'-alkylC6-amine

Cat. No. 7923 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cereblon ligand with alkyl linker and terminal amine for onward chemistry
化学名： 4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
纯度： ≥95% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for Pomalidomide 4'-alkylC6-amine

Pomalidomide 4'-alkylC6-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC6 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Pomalidomide - linker 4

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for Pomalidomide 4'-alkylC6-amine

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for Pomalidomide 4'-alkylC6-amine

分子量 408.88
公式 C19H24N4O4.HCl
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2375194-37-7
PubChem ID 139211246
InChI Key PBGMRXNTLPSDNR-UHFFFAOYSA-N
Smiles Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCCCN)C3C2=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Pomalidomide 4'-alkylC6-amine

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Pomalidomide 4'-alkylC6-amine

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关键词: Pomalidomide 4'-alkylC6-amine, Pomalidomide 4'-alkylC6-amine supplier, PROTACs, components, cereblon, E3, ubiquitin, ligase, Alkyl, linker, conjugate, building, blocks, ligands, targeted, protein, degradation, TPD, Cereblon, Ligands, Plus, Linkers, 7923, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia