PQ 401

Cat. No. 2768 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： IGF1R inhibitor

化学名： N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea

纯度： ≥99% (HPLC)

引用文献 (5)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PQ 401

PQ 401 is an insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC₅₀ value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.

化合物库 for PQ 401

PQ 401 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PQ 401

分子量	341.79
公式	C₁₈H₁₆ClN₃O₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	196868-63-0
PubChem ID	9549305
InChI Key	YBLWOZUPHDKFOT-UHFFFAOYSA-N
Smiles	O=C(NC3=C(OC)C=CC(Cl)=C3)NC2=CC(C)=NC1=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PQ 401

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	17.09	50
	ethanol	8.54	25

制备储备液 for PQ 401

以下数据基于产品分子量 341.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.85 mL	29.26 mL	58.52 mL
2.5 mM	1.17 mL	5.85 mL	11.7 mL
5 mM	0.59 mL	2.93 mL	5.85 mL
25 mM	0.12 mL	0.59 mL	1.17 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for PQ 401

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PQ 401

参考文献是支持产品生物活性的出版物。

Anderson et al (2006) Parallel synthesis of diarylureas and their evaluation as inhibitors of Ins-like growth factor receptor. J.Comb.Chem. 8 784 PMID: 16961415

Sivakumar et al (2009) Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. 34 329 PMID: 19148466

Gable et al (2006) Diarylureas are small-molecule inhibitors of Ins-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 5 1079 PMID: 16648580

If you know of a relevant reference for PQ 401, please let us know.

按标靶查看相关产品

关键词: PQ 401, PQ 401 supplier, IGF-IR, inhibitors, inhibits, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, RTKs, PQ401, Insulin, and, insulin-like, 2768, Tocris Bioscience

5 篇 PQ 401 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PQ 401 的部分引用包括：

Sanchez-Alavez et al (2011) Ins-like growth factor 1-mediated hyperthermia involves anterior hypothalamic Ins receptors. J Biol Chem 286 14983 PMID: 21330367

Jameson et al (2011) Activation of the Ins-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells. Mol Cancer Ther 10 2124 PMID: 21878657

Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730

Shen et al (2012) Ins-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling. Mol Cell Biol 32 4116 PMID: 22869525

Radhakrishnan et al (2010) Ins-like growth factor-I-stimulated Ins receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells. J Biol Chem 285 15682 PMID: 20207740

您是否知道使用了 Tocris PQ 401 的优秀论文？请告知我们.

PQ 401 的评论

目前没有该产品的评论。 Be the first to review PQ 401 and earn rewards!

Have you used PQ 401?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for PQ 401

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.