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Submit ReviewPrasugrel
说明： Irreversible P2Y12 antagonist; antiplatelet and orally active
别名： LY640315,CS 747,Effient
化学名： 2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone
纯度： ≥98% (HPLC)
生物活性 for Prasugrel
Prasugrel is an irreversible P2Y12 antagonist; metabolised to active metabolite R-99224 (IC50 = 45 μM) irreversibly binds platelet P2Y12 receptors, inhibiting platelet activation. Antiplatelet and antithrombotic. Orally active and active in vivo. Note - inactive in vitro.
化合物库 for Prasugrel
Prasugrel is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Prasugrel
| 分子量 | 373.44 |
| 公式 | C20H20FNO3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 150322-43-3 |
| PubChem ID | 6918456 |
| InChI Key | DTGLZDAWLRGWQN-UHFFFAOYSA-N |
| Smiles | CC(OC1=CC2=C(S1)CCN(C(C3=C(C=CC=C3)F)C(C4CC4)=O)C2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Prasugrel
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 37.34 | 100 |
制备储备液 for Prasugrel
以下数据基于产品分子量 373.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.39 mL | 26.78 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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产品说明书 for Prasugrel
参考文献 for Prasugrel
参考文献是支持产品生物活性的出版物。
Sugidachi et al (2000) The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br.J.Pharmacol. 129 1439 PMID: 10742300
Hashimoto (2007) The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of pras. in a mouse model: evidence for specific inhibition of P2Y12 receptors by pras. Biochem.Pharmacol. 74 1003 PMID: 17681285
Huber et al (2009) Prasugrel. Nat.Rev.Drug Discov. 8 449 PMID: 19483707
If you know of a relevant reference for Prasugrel, please let us know.
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关键词: Prasugrel, Prasugrel supplier, LY640315, Prasugrel, P2Y12, purinergic, antagonists, receptors, purinoceptors, adenosine, CS_747, CS747, Effient, Efient, antiplatelet, atherosclerosis, antithromboembolic, orally, active, in, vivo, antagonises, inhibitors, inhibits, CS, 747, Purinergic, P2Y, Receptors, 6317, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.