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Submit ReviewPSB 0474
Discontinued Product
This product has been withdrawn from sale and is superseded by MRS 2957 triethylammonium salt (Cat. No. 4260)
说明： Potent and selective P2Y6 agonist
别名： 3-Phenacyl UDP disodium salt
化学名： 3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphate disodium salt
纯度： ≥98% (HPLC)
生物活性 for PSB 0474
PSB 0474 is a potent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.
技术数据 for PSB 0474
| 分子量 | 566.26 |
| 公式 | C17H18N2Na2O13P2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 54591398 |
| InChI Key | LEICCBKKYICWFH-BWBFMJMBSA-L |
| Smiles | [Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP(O)([O-])=O)N1C=CC(=O)N(CC(=O)C2=CC=CC=C2)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PSB 0474
参考文献 for PSB 0474
参考文献是支持产品生物活性的出版物。
El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076 PMID: 17125260
Mitchell et al (2012) Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. J.Pharmacol.Exp.Ther. 343 755 PMID: 22991416
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关键词: PSB 0474, PSB 0474 supplier, Potent, selective, P2Y6, agonists, Receptors, Purinergic, purinoceptors, PSB0474, 917567-60-3, 3-Phenacyl, UDP, disodium, salt, P2Y, 2715, Tocris Bioscience
5 篇 PSB 0474 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PSB 0474 的部分引用包括：
Carneiro et al (2014) Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium. Br J Pharmacol 171 3404 PMID: 24697602
Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406
Quintas et al (2014) Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation 11 141 PMID: 25178395
Kataoka et al (2011) Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways. Purinergic Signal 7 403 PMID: 21567128
Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Exp Eye Res 9 31 PMID: 22825617
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.