PSB 10 hydrochloride

Cat. No. 2010 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, highly selective hA₃ receptor antagonist/inverse agonist

化学名： (8R)-8-Ethyl-1,4,7,8-tetrahydro-4-methyl-2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin-5-one monohydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PSB 10 hydrochloride

PSB 10 hydrochloride is a potent and highly selective antagonist for the human adenosine A₃ receptor, with low affinity for the rat A₃ receptor (K_i values are 0.44 and > 17000 nM respectively). Displays > 3800-fold selectivity over human A₁, A_2A and A_2B receptors (K_i values are 4.1, 3.3 and 30 μM respectively) and > 1800-fold selectivity over rat A₁ and A_2A receptors. Acts as an inverse agonist in the [³⁵S]GTPγS binding assay in hA₃-CHO cells (IC₅₀ = 4 nM). Produces thermal hyperalgesia in mice in vivo.

化合物库 for PSB 10 hydrochloride

PSB 10 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PSB 10 hydrochloride

分子量	435.14
公式	C₁₆H₁₄Cl₃N₅O.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	591771-91-4
PubChem ID	90488733
InChI Key	JUPMOTHIKGWECW-DDWIOCJRSA-N
Smiles	CC[C@H](C3)N=C1N3C(N(C)C2=C1NC(C4=C(Cl)C(Cl)=CC(Cl)=C4)=N2)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PSB 10 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	10.88	25
	ethanol	4.35	10

制备储备液 for PSB 10 hydrochloride

以下数据基于产品分子量 435.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	9.19 mL	45.96 mL	91.92 mL
1.25 mM	1.84 mL	9.19 mL	18.38 mL
2.5 mM	0.92 mL	4.6 mL	9.19 mL
12.5 mM	0.18 mL	0.92 mL	1.84 mL

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产品说明书 for PSB 10 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PSB 10 hydrochloride

参考文献是支持产品生物活性的出版物。

Muller (2003) Medicinal chemistry of adenosine A₃ receptor ligands. Curr.Top.Med.Chem. 3 445 PMID: 12570761

Ozola et al (2003) 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at human A₃ adenosine receptors. Bioorg.Med.Chem. 11 347 PMID: 12517430

Abo-Salem et al (2004) Antinociceptive effects of novel A_2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther. 308 358 PMID: 14563788

If you know of a relevant reference for PSB 10 hydrochloride, please let us know.

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关键词: PSB 10 hydrochloride, PSB 10 hydrochloride supplier, Potent, selective, human, A3, receptors, antagonists, inverse, agonists, adenosines, PSB10, hydrochloride, HCl, Adenosine, Receptors, 2010, Tocris Bioscience

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