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Submit ReviewPSB 12379
说明： Ecto-5'-nucleotidase (CD73) inhibitor
化学名： N6-Benzyl-α,β-methyleneadenosine 5'-diphosphate disodium salt
纯度： ≥98% (HPLC)
生物活性 for PSB 12379
PSB 12379 is a selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (Ki values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.
技术数据 for PSB 12379
| 分子量 | 559.31 |
| 公式 | C18H21N5Na2O9P2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 131648246 |
| InChI Key | CGXINRNHTNDEBI-BUPZQQHBSA-L |
| Smiles | O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1COP(CP(O)(O[Na])=O)(O[Na])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PSB 12379
| 溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
产品说明书 for PSB 12379
参考文献 for PSB 12379
参考文献是支持产品生物活性的出版物。
Bhattarai et al (2015) α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors. J.Med.Chem. 58 6248 PMID: 26147331
Weinmann et al (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450 PMID: 26836578
If you know of a relevant reference for PSB 12379, please let us know.
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关键词: PSB 12379, PSB 12379 supplier, PSB12379, selective, high, affinity, CD73, inhibitors, inhibits, 1802226-78-3, NTPDase, 6083, Tocris Bioscience
2 篇 PSB 12379 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PSB 12379 的部分引用包括：
Istvan et al (2022) Microglial control of neuronal development via somatic purinergic junctions. Cell Rep 40 111369 PMID: 36130488
Hyunjung et al (2020) Activation of Astrocytes in the Dorsomedial Striatum Facilitates Transition From Habitual to Goal-Directed Reward-Seeking Behavior. Biol Psychiatry 88 797-808 PMID: 32564901
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.