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PSB CB5

Cat. No. 6372 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective GPR18 antagonist
化学名： (2Z)-2[[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PSB CB5

PSB CB5 is a selective GPR18 antagonist (IC50 = 0.279 μM). Exhibits >36-fold selectivity versus CB1 and GPR55 and 14-fold selectivity versus CB2 receptors. Inhibits N-Arachidonylglycine (Cat. No. 1445) induced acrosomal exocytosis in human spermatozoa.

化合物库 for PSB CB5

PSB CB5 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PSB CB5

分子量 384.88
公式 C20H17ClN2O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1627710-30-8
PubChem ID 85469571
InChI Key XJBQRMOGMULGPP-PDGQHHTCSA-N
Smiles O=C(N1C(SCCC1)=N/2)C2=C\C3=CC(OCC4=CC=C(Cl)C=C4)=CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PSB CB5

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.7 20

制备储备液 for PSB CB5

以下数据基于产品分子量 384.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 12.99 mL 64.96 mL 129.91 mL
1 mM 2.6 mL 12.99 mL 25.98 mL
2 mM 1.3 mL 6.5 mL 12.99 mL
10 mM 0.26 mL 1.3 mL 2.6 mL

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参考文献 for PSB CB5

参考文献是支持产品生物活性的出版物。

Rempel et al (2014) Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med.Chem.Comm. 5 632

Flegel et al (2016) Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci.Rep. 6 32255 PMID: 27572937

If you know of a relevant reference for PSB CB5, please let us know.

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关键词: PSB CB5, PSB CB5 supplier, PSBCB5, GPR18, selective, antagonist, Other, Cannabinoids, 6372, Tocris Bioscience

1 篇 PSB CB5 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PSB CB5 的部分引用包括：

Michael N et al (2023) N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness. iScience 26 106578 PMID: 37128607

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该领域的文献

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Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.