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说明： Negative allosteric modulator of CB1 receptors
化学名： N-(4-Chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]urea
纯度： ≥99% (HPLC)
生物活性 for PSNCBAM-1
PSNCBAM-1 is a CB1 receptor negative allosteric modulator (IC50 values are 45 and 209 nM for the inhibition of CP 55,940 and WIN 55,212-2 respectively). Has no effect at the CB2 receptor. Decreases food intake and body weight in rats.
化合物库 for PSNCBAM-1
PSNCBAM-1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for PSNCBAM-1
| 分子量 | 392.88 |
| 公式 | C22H21ClN4O |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 877202-74-9 |
| PubChem ID | 11560249 |
| InChI Key | HDAYFSFWIPRJSO-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(NC2=CC(C3=CC=CC(N4CCCC4)=N3)=CC=C2)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PSNCBAM-1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 39.29 | 100 |
制备储备液 for PSNCBAM-1
以下数据基于产品分子量 392.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.73 mL | 25.45 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.09 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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产品说明书 for PSNCBAM-1
参考文献 for PSNCBAM-1
参考文献是支持产品生物活性的出版物。
Horswill et al (2007) PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br.J.Pharmacol. 152 805 PMID: 17592509
German et al (2014) Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J.Med.Chem. 57 7758 PMID: 25162172
If you know of a relevant reference for PSNCBAM-1, please let us know.
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关键词: PSNCBAM-1, PSNCBAM-1 supplier, subtype, selective, cb1, cannabinoids, receptors, negative, allosteric, modulators, antagonists, hypophagic, NAM, CB1, Receptors, 5321, Tocris Bioscience
篇 PSNCBAM-1 的引用文献
引用文献是使用了 Tocris 产品的出版物。
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PSNCBAM-1 的评论
平均评分: 5 (Based on 1 Review.)
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Works as described, another very interesting compound..
By
Jonathan Fay on 05/30/2019
分析类型： In Vitro
种属： Human
细胞系/组织： COSH-1
Allosteric enhancement of radiolabeled agonist binding.
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