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Psora 4

Cat. No. 4367 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent KV1.3 channel blocker
化学名： 4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Psora 4

Psora 4 is a potent KV1.3 channel blocker (EC50 = 3 nM). Preferentially binds the C-type inactivated state of the channel, similar to the activity of CP 339818 (Cat. No. 1399). Displays 17- to 70-fold selectivity over closely-related KV1 channels (KV1, KV2, KV4 and KV7); exhibits activity at KV1.5 (IC50 = 7.7 nM). Suppresses proliferation of human and rat myelin-specific effector memory T cells (EC50 values are 25 and 60 nM respectively).

技术数据 for Psora 4

分子量 334.37
公式 C21H18O4
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 724709-68-6
PubChem ID 6603977
InChI Key JJAWGNIQEOFURP-UHFFFAOYSA-N
Smiles O=C2OC1=CC3=C(C=CO3)C(OCCCCC4=CC=CC=C4)=C1C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Psora 4

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 16.72 50
ethanol 3.34 10

制备储备液 for Psora 4

以下数据基于产品分子量 334.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.98 mL 29.91 mL 59.81 mL
2.5 mM 1.2 mL 5.98 mL 11.96 mL
5 mM 0.6 mL 2.99 mL 5.98 mL
25 mM 0.12 mL 0.6 mL 1.2 mL

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参考文献 for Psora 4

参考文献是支持产品生物活性的出版物。

Vennekamp et al (2004) Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol.Pharmacol. 65 1364 PMID: 15155830

Schmitz et al (2005) Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol.Pharmacol. 68 1254 PMID: 16099841

Li et al (2006) Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. Am.J.Physiol.Cell Physiol. 290 C345 PMID: 16403947

If you know of a relevant reference for Psora 4, please let us know.

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关键词: Psora 4, Psora 4 supplier, Psora4, Kv1.3, selective, ion, channels, blockers, potent, KV13, Potassium, KV, voltage-gated, voltage-dependent, K+, Voltage-Gated, Channels, 4367, Tocris Bioscience

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Psora 4 的评论

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Psora 4 was used on Kv3.1 channels to assess the blocking action exerted.
By Anonymous on 02/27/2019
种属： Human

Psora 4 was used on Kv3.1 channels in increasing concentrations to assess the blocking action exerted by Psora 4.Works ideally and gives publishable results.

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