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说明： Potent MMP-3 expression inhibitor; neuroprotective
化学名： 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone
纯度： ≥98% (HPLC)
生物活性 for PTIQ
PTIQ is a potent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.
技术数据 for PTIQ
| 分子量 | 235.28 |
| 公式 | C13H17NO3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1032822-42-6 |
| PubChem ID | 24812799 |
| InChI Key | BEDYMEDICHGLSE-UHFFFAOYSA-N |
| Smiles | O=C(CC)N2CC1=CC(O)=C(OC)C=C1CC2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PTIQ
参考文献 for PTIQ
参考文献是支持产品生物活性的出版物。
Son et al (2012) A novel compound PTIQ protects the nigral DArgic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213 PMID: 21951056
Seo et al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160 PMID: 17980460
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