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Pyrimethamine

Cat. No. 3918 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor
化学名： 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Pyrimethamine

Pyrimethamine is a potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.

化合物库 for Pyrimethamine

Pyrimethamine is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Pyrimethamine

分子量 248.71
公式 C12H13ClN4
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 58-14-0
PubChem ID 4993
InChI Key WKSAUQYGYAYLPV-UHFFFAOYSA-N
Smiles ClC1=CC=C(C2=C(N)N=C(N)N=C2CC)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pyrimethamine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.87 100
ethanol 2.49 10

制备储备液 for Pyrimethamine

以下数据基于产品分子量 248.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.02 mL 20.1 mL 40.21 mL
5 mM 0.8 mL 4.02 mL 8.04 mL
10 mM 0.4 mL 2.01 mL 4.02 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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参考文献 for Pyrimethamine

参考文献是支持产品生物活性的出版物。

Ito et al (2010) Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimeth. J.Pharmacol.Exp.Ther. 333 341 PMID: 20065018

Zimmerman et al (1987) Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimeth. and pyrimeth. Am.J.Clin.Nutr. 46 518 PMID: 3630970

Takakura et al (2011) Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum.Mol.Genet. 20 4143 PMID: 21821671

If you know of a relevant reference for Pyrimethamine, please let us know.

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关键词: Pyrimethamine, Pyrimethamine supplier, inhibitors, inhibits, multidrug, and, toxin, extrusion, MATE, transporters, dihydrofolate, reductase, DHFR, STAT3, signal, transducer, activator, of, transcription, 3, Multidrug, Transporters, Dihydrofolate, Reductase, STAT, 3918, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Pyrimethamine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

1 篇 Pyrimethamine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pyrimethamine 的部分引用包括：

Hui et al (2020) Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones. Cell Chem Biol 27 622-634.e6 PMID: 32330442

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