STATs
STATs (signal transducers and activators of transcription) are a family of seven transcription factors that form part of the JAK-STAT signaling cascade, the basis of the signal transduction mechanism for many cytokine receptors. STATs are activated by phosphorylation by JAKs.
STAT Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 7636 | AS 1517499 |
| STAT6 inhibitor | |
| 1571 | Cucurbitacin I |
| Selective inhibitor of STAT3/JAK2 signaling | |
| 6110 | HJC 0416 hydrochloride |
| STAT3 inhibitor | |
| 5522 | Napabucasin |
| STAT3 inhibitor; also blocks cancer stem cell self-renewal | |
| 4079 | Niclosamide |
| STAT3 inhibitor; also inhibits mTORC1 signaling | |
| 4655 | NSC 74859 |
| Selective STAT3 inhibitor | |
| 3918 | Pyrimethamine |
| STAT3 inhibitor; also potent inhibitor of multidrug and toxin extrusion (MATE) transporters and DHFR inhibitor | |
| 3035 | SD 1008 |
| JAK2/STAT3 signaling pathway inhibitor | |
| 2798 | Stattic |
| Selective STAT3 inhibitor | |
STAT Activators |
|
| Cat. No. | Product Name / Activity |
| 3945 | Colivelin |
| STAT3 activator; also protects against β-amyloid neurotoxicity | |
Other |
|
| Cat. No. | Product Name / Activity |
| 3495 | Fludarabine |
| Purine analog; inhibits cytokine-induced STAT1 activation | |
STATs (signal transducers and activators of transcription) are a family of seven transcription factors that form part of the JAK-STAT signaling cascade. This cascade is the basis of the signal transduction mechanism for many cytokine receptors. Once activated by phosphorylation by JAKs, STATs translocate to the nucleus.
Accumulation of STATs in the nucleus is both rapid and tightly controlled. A number of factors regulate the JAK-STAT pathway including STAT dephosphorylation by phosphatases, altered nuclear import-export dynamics of STAT, and STAT gene activation antagonists such as SOCS (suppressors of cytokine signaling) and PIAS (Protein Inhibitors of Activated STATs).
Pathways for STATs
JAK-STAT Signaling Pathway
The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.STAT Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| STAT1 | Human | STAT1 | NM_007315 | P42224 |
| Mouse | Stat1 | NM_009283 | P42225 | |
| Rat | Stat1 | NM_032612 | Q9QXK0 | |
| STAT2 | Human | STAT2 | NM_005419 | P52630 |
| Mouse | Stat2 | NM_019963 | Q9WVL2 | |
| Rat | Stat2 | NM_001011905 | Q5XI26 | |
| STAT3 | Human | STAT3 | NM_139276 | P40763 |
| Mouse | Stat3 | NM_213659 | P42227 | |
| Rat | Stat3 | NM_012747 | P52631 | |
| STAT4 | Human | STAT4 | NM_003151 | Q14765 |
| Mouse | Stat4 | NM_011487 | P42228 | |
| Rat | Stat4 | NM_001012226 | O70428 | |
| STAT5A | Human | STAT5A | NM_003152 | P42229 |
| Mouse | Stat5a | NM_011488 | P42230 | |
| Rat | Stat5a | NM_017064 | Q62771 | |
| STAT5B | Human | STAT5B | NM_012448 | P51692 |
| Mouse | Stat5b | NM_011489 | P42232 | |
| Rat | Stat5b | NM_022380 | P52632 | |
| STAT6 | Human | STAT6 | NM_003153 | P42226 |
| Mouse | Stat6 | NM_009284 | P52633 | |
| Rat | Stat6 | NM_001044250 | O70429 |