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Pyrrolidinedithiocarbamate ammonium

Cat. No. 0727 8 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0727 has been discontinued.

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说明： Inhibits NF-κB, prevents increase in NOS mRNA
别名： PDTC
说明书
引用文献 (8)
评论 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Pyrrolidinedithiocarbamate ammonium

This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.

技术数据 for Pyrrolidinedithiocarbamate ammonium

分子量 164.28
公式 C5H12N2S2
储存 Store at RT
CAS Number 5108-96-3
PubChem ID 73343
InChI Key MDDIUTVUBYEEEM-UHFFFAOYSA-N
Smiles [NH4+].[S-]C(N1CCCC1)=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Pyrrolidinedithiocarbamate ammonium

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Pyrrolidinedithiocarbamate ammonium

参考文献是支持产品生物活性的出版物。

Bessho et al (1994) Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem.Pharmacol. 48 1883 PMID: 7986199

Eberhardt et al (1994) Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells. Biochem.Biophys.Res.Commun. 200 163 PMID: 7513157

Schini-Kerth (1994) Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur.J.Pharmacol. 265 83 PMID: 7533726

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关键词: Pyrrolidinedithiocarbamate ammonium, Pyrrolidinedithiocarbamate ammonium supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, NOS, mRNA, NFκB, NFkappaB, Nitric, Oxide, Signaling, Signalling, IκB, IkappaB, Nuclear, Factor, Kappa, B, Transcription, Factors, PDTC, Other, NF-kB/IkB, 0727, Tocris Bioscience

8 篇 Pyrrolidinedithiocarbamate ammonium 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pyrrolidinedithiocarbamate ammonium 的部分引用包括：

Li et al (2017) Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics 7 4671 PMID: 29187895

Wang et al (2015) Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B virus-related hepatocellular carcinoma via ERK1/2 signaling. Sci Rep 15 821 PMID: 26514586

Lin et al (2015) Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis. J Neurosci 5 12463 PMID: 26198099

Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092 PMID: 27554194

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PDTC inhibits HOCl-LDL-induced CaMKII oxidation.
By Chintan Koyani on 10/22/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Cardiomyocytes

HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.

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Pathways for Pyrrolidinedithiocarbamate ammonium

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.