PZM21

Cat. No. 7218 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective μ receptor agonist

化学名： N-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]urea

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PZM21

PZM21 is a selective μ receptor agonist (EC₅₀ = 4.6 nM). PZM21 has been reported to exhibit bias for the G_i signaling pathway over arrestin-3. The compound exhibits 500-fold selectivity for μ over δ receptors and no detectable activity at κ or nociceptin receptors and a panel of 316 other GPCRs. PZM21 induces analgesia in a mouse hot plate assay, but not a tail-flick assay and exhibits no significant conditioned place preference response in in vivo assays. CNS penetrant.

化合物库 for PZM21

PZM21 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PZM21

分子量	361.5
公式	C₁₉H₂₇N₃O₂S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1997387-43-5
PubChem ID	121596705
InChI Key	MEDBIJOVZJEMBI-YOEHRIQHSA-N
Smiles	C[C@H](NC(NC[C@@H](N(C)C)CC1=CC=C(C=C1)O)=O)CC2=CSC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PZM21

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	36.15	100
	ethanol	36.15	100

制备储备液 for PZM21

以下数据基于产品分子量 361.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.83 mL	27.66 mL
5 mM	0.55 mL	2.77 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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产品说明书 for PZM21

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PZM21

参考文献是支持产品生物活性的出版物。

Manglik et al (2016) Structure-based discovery of opioid analgesics with reduced side effects. Nature 537 185 PMID: 27533032

Hill et al (2018) The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception. Br.J.Pharmacol. 175 2653 PMID: 29582414

If you know of a relevant reference for PZM21, please let us know.

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关键词: PZM21, PZM21 supplier, selective, mu, opioid, receptor, agonist, μ, analgesic, brain, penetrant, Mu, Opioid, Receptors, 7218, Tocris Bioscience

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