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QAQ dichloride

Cat. No. 5470 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Photoswitchable Nav, Kv and Cav channel blocker
化学名： 2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for QAQ dichloride

QAQ dichloride is a photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.

技术数据 for QAQ dichloride

分子量 567.59
公式 C28H44Cl2N6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
PubChem ID 91826091
InChI Key VHURBRSYOFCHNY-UHFFFAOYSA-N
Smiles O=C(C[N+](CC)(CC)CC)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-].[Cl-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for QAQ dichloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 28.38 50

制备储备液 for QAQ dichloride

以下数据基于产品分子量 567.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.52 mL 17.62 mL 35.24 mL
2.5 mM 0.7 mL 3.52 mL 7.05 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
25 mM 0.07 mL 0.35 mL 0.7 mL

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参考文献 for QAQ dichloride

参考文献是支持产品生物活性的出版物。

Mourot et al (2012) Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 9 396 PMID: 22343342

Banghart MR et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID: 19882609

If you know of a relevant reference for QAQ dichloride, please let us know.

按标靶查看相关产品

关键词: QAQ dichloride, QAQ dichloride supplier, photoswitchable, Kv, potassium, channels, K+, blockers, Ca2+, Cav, calcium, Na+, Nav, sodium, local, anesthesia, anesthetic, ligands, Photoswitchable, Ligands, Non-selective, Channels, Voltage-Gated, Potassium, Voltage-gated, Sodium, 5470, Tocris Bioscience

1 篇 QAQ dichloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 QAQ dichloride 的部分引用包括：

Nikolaev et al (2022) Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors. Eur.J.Pharmacol. 938 175448 PMID: 36470444

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