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Submit ReviewQAQ dichloride
说明： Photoswitchable Nav, Kv and Cav channel blocker
化学名： 2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride
纯度： ≥98% (HPLC)
生物活性 for QAQ dichloride
QAQ dichloride is a photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.
技术数据 for QAQ dichloride
| 分子量 | 567.59 |
| 公式 | C28H44Cl2N6O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 91826091 |
| InChI Key | VHURBRSYOFCHNY-UHFFFAOYSA-N |
| Smiles | O=C(C[N+](CC)(CC)CC)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-].[Cl-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for QAQ dichloride
参考文献 for QAQ dichloride
参考文献是支持产品生物活性的出版物。
Mourot et al (2012) Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 9 396 PMID: 22343342
Banghart MR et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID: 19882609
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关键词: QAQ dichloride, QAQ dichloride supplier, photoswitchable, Kv, potassium, channels, K+, blockers, Ca2+, Cav, calcium, Na+, Nav, sodium, local, anesthesia, anesthetic, ligands, Photoswitchable, Ligands, Non-selective, Channels, Voltage-Gated, Potassium, Voltage-gated, Sodium, 5470, Tocris Bioscience
1 篇 QAQ dichloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 QAQ dichloride 的部分引用包括：
Nikolaev et al (2022) Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors. Eur.J.Pharmacol. 938 175448 PMID: 36470444
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