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说明： Non-competitive and GluN2C/GluN2D-selective NMDA antagonist
化学名： 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for QNZ 46
QNZ 46 is a GluN2C/GluN2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for GluN2D, GluN2C, GluN2A, GluN2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
化合物库 for QNZ 46
QNZ 46 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for QNZ 46
| 分子量 | 443.41 |
| 公式 | C24H17N3O6 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1237744-13-6 |
| PubChem ID | 46861929 |
| InChI Key | GNLVJIICVWDSNI-LFYBBSHMSA-N |
| Smiles | O=C2C1=CC(OC)=CC=C1N=C(/C=C/C4=CC([N+]([O-])=O)=CC=C4)N2C3=CC=C(C(O)=O)C=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for QNZ 46
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 4.43 | 10 温和加热 |
制备储备液 for QNZ 46
以下数据基于产品分子量 443.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.55 mL | 112.76 mL | 225.52 mL |
| 0.5 mM | 4.51 mL | 22.55 mL | 45.1 mL |
| 1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
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产品说明书 for QNZ 46
参考文献 for QNZ 46
参考文献是支持产品生物活性的出版物。
Mosley et al (2010) Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-MthD.-aspartate receptor antagonists. J.Med.Chem. 53 5476 PMID: 20684595
Hansen and Traynelis (2011) Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J.Neurosci. 31 3650 PMID: 21389220
If you know of a relevant reference for QNZ 46, please let us know.
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关键词: QNZ 46, QNZ 46 supplier, QNZ46, Glu, NR2C, NR2D, antagonists, glutamate, NMDA, receptors, GluN2C, GluN2D, Receptors, 4801, Tocris Bioscience
2 篇 QNZ 46 的引用文献
引用文献是使用了 Tocris 产品的出版物。 QNZ 46 的部分引用包括：
Brancaccio et al (2017) Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron 93 1420 PMID: 28285822
Robert H et al (2020) Astrocytes Are Required for Oligodendrocyte Survival and Maintenance of Myelin Compaction and Integrity. Front Cell Neurosci 14 74 PMID: 32300294
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