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QO 58

Cat. No. 5083 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Kv7 channel opener
化学名： 5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for QO 58

QO 58 is a Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.

化合物库 for QO 58

QO 58 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for QO 58

分子量 443.18
公式 C18H8Cl2F4N4O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1259536-62-3
PubChem ID 51351551
InChI Key ZOLHKPWSDFSDKA-UHFFFAOYSA-N
Smiles O=C1C=C(C4=CC(F)=C(Cl)N=C4Cl)NC2=C(C3=CC=CC=C3)C(C(F)(F)F)=NN12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for QO 58

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.16 50

制备储备液 for QO 58

以下数据基于产品分子量 443.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.51 mL 22.56 mL 45.13 mL
2.5 mM 0.9 mL 4.51 mL 9.03 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
25 mM 0.09 mL 0.45 mL 0.9 mL

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参考文献 for QO 58

参考文献是支持产品生物活性的出版物。

Zhang et al (2013) Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br.J.Pharmacol. 168 1030 PMID: 23013484

Qi et al (2011) Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur.J.Med.Chem. 46 934 PMID: 21296466

If you know of a relevant reference for QO 58, please let us know.

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关键词: QO 58, QO 58 supplier, Kv7, openers, K+, channel, activators, voltage, gated, potassium, channels, neuropathic, pain, Voltage-Gated, Potassium, Channels, 5083, Tocris Bioscience

篇 QO 58 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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QO 58 的评论

平均评分: 5 (Based on 1 Review.)

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QO 58 used for to understand channel opening properties.
By Anonymous on 10/13/2018
分析类型： In Vitro
种属： Human

Our University lab used this product for years to study channel opening properties. Worked great on lab conditions and shows different rates on channel opening on different cell lines. Great product, would buy again and recommend.

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