Quetiapine hemifumarate

Cat. No. 4735 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： 5-HT₂ antagonist; also D₂ antagonist; atypical antipsychotic

别名： ICI 204,636

化学名： 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate

纯度： ≥99% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Quetiapine hemifumarate

Quetiapine hemifumarate is an atypical antipsychotic. Displays antagonist activity at serotonin (5-HT₂) and dopamine (D₂) receptors (IC₅₀ values are 148 and 329 nM respectively). Lacks affinity at either D₁ or muscarinic receptors.

化合物库 for Quetiapine hemifumarate

Quetiapine hemifumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Quetiapine hemifumarate

分子量	441.54
公式	C₂₁H₂₅N₃O₂S.0.5C₄H₄O₄
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	111974-72-2
PubChem ID	5281025
InChI Key	ZTHJULTYCAQOIJ-WXXKFALUSA-N
Smiles	OCCOCCN(CC4)CCN4C2=NC1=CC=CC=C1SC3=C2C=CC=C3.O=C(/C=C/C(O)=O)O.OCCOCCN(CC8)CCN8C6=NC5=CC=CC=C5SC7=C6C=CC=C7

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Quetiapine hemifumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	22.08	50

制备储备液 for Quetiapine hemifumarate

以下数据基于产品分子量 441.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.53 mL	22.65 mL	45.3 mL
2.5 mM	0.91 mL	4.53 mL	9.06 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
25 mM	0.09 mL	0.45 mL	0.91 mL

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产品说明书 for Quetiapine hemifumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Quetiapine hemifumarate

参考文献是支持产品生物活性的出版物。

Saller and Salama (1993) Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl.) 112 285 PMID: 7871032

Ellenbroek et al (1996) Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with cloz. Neuropsychopharmacology 15 406 PMID: 8887995

If you know of a relevant reference for Quetiapine hemifumarate, please let us know.

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关键词: Quetiapine hemifumarate, Quetiapine hemifumarate supplier, antipsychotics, serotonin, 5-HT, 5-HT2, dopamine, D2, receptors, ICI204636, antagonists, ICI, 204,636, Non-selective, Receptors, 4735, Tocris Bioscience

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