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Quizartinib

Cat. No. 6788 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly potent FLT3 inhibitor
化学名： N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Quizartinib

Quizartinib is a highly potent FMS-like receptor tyrosine kinase-3 (FLT3) inhibitor (Kd = 1.6 nM, IC50 = 0.56 nM in MV4-11 cell proliferation assay). Displays >10-fold selectivity for FLT3 over panel of 400 kinases. Inhibits FLT3 activity and displays antitumor properties in a mouse MV4-11 tumor xenograft model.

化合物库 for Quizartinib

Quizartinib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Quizartinib

分子量 560.67
公式 C29H32N6O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 950769-58-1
PubChem ID 24889392
InChI Key CVWXJKQAOSCOAB-UHFFFAOYSA-N
Smiles CC(C)(C1=CC(NC(NC2=CC=C(C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3)C=C2)=O)=NO1)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Quizartinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 56.07 100

制备储备液 for Quizartinib

以下数据基于产品分子量 560.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Molarity Calculator

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参考文献 for Quizartinib

参考文献是支持产品生物活性的出版物。

Chao et al (2009) Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like ty J.Med.Chem. 52 7808 PMID: 19754199

Zarrinkar et al (2009) AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 114 2984 PMID: 19654408

If you know of a relevant reference for Quizartinib, please let us know.

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关键词: Quizartinib, Quizartinib supplier, FLT3, inhibitors, inhibits, FMS-like, receptor, tyrosine, kinase-3, CD135, acute, myeloid, leukemia, AML, 6788, Tocris Bioscience

1 篇 Quizartinib 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Quizartinib 的部分引用包括：

Thoas et al (2021) Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells. Haematologica 106 2566-2577 PMID: 32855276

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