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Submit Review(R)-(+)-Methanandamide (in Tocrisolve™ 100)
说明： Potent and selective CB1 agonist; supplied in water-soluble emulsion
化学名： (R)-N-(2-Hydroxy-1-methylethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
生物活性
Stable anandamide analog that is a selective agonist for the CB1 receptor (Ki values are 20 and 815 nM for CB1 and CB2 receptors respectively), in water-soluble emulsion (for details see TocrisolveTM 100). Displays agonist activity at vanilloid receptors.
(R)-(+)-Methanandamide, pure oil dissolved in ethanol and Tocrisolve Control also available.
技术数据
| 分子量 | 361.57 |
| 公式 | C23H39NO2 |
| 储存 | Store at +4°C |
| CAS Number | 157182-49-5 |
| PubChem ID | 6321351 |
| InChI Key | SQKRUBZPTNJQEM-FQPARAGTSA-N |
| Smiles | O=C(N[C@H](C)CO)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书
参考文献
参考文献是支持产品生物活性的出版物。
Abadji et al (1994) (R)-Methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J.Med.Chem. 37 1889 PMID: 8021930
Carriero et al (1998) A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing. Psychopharmacology (Berl.) 137 147 PMID: 9630001
Khanolkar et al (1996) Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J.Med.Chem. 39 4515 PMID: 8893848
Zygmunt et al (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400 452 PMID: 10440374
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关键词: (R)-(+)-Methanandamide (in TocrisolveTM 100), (R)-(+)-Methanandamide (in TocrisolveTM 100) supplier, Potent, selective, CB1, agonists, water-soluble, emulsion, cannabinoids, Receptors, cb1r, TocrisolveTM100, 1782, Tocris Bioscience
3 篇 (R)-(+)-Methanandamide (in Tocrisolve™ 100) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (R)-(+)-Methanandamide (in Tocrisolve™ 100) 的部分引用包括：
Grace et al (2014) Identification of a pharmacological target for genioglossus reactivation throughout sleep. Int J Neuropsychopharmacol 37 41 PMID: 24470694
Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. J Neuroimmune Pharmacol 17 1943 PMID: 24485144
Garzón et al (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor. Mol Pain 5 11 PMID: 19284549
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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