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(R)-(-)-Rolipram

Cat. No. 1349 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)
化学名： (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (R)-(-)-Rolipram

(R)-(-)-Rolipram is a more active enantiomer of the PDE4 inhibitor rolipram; 2-10-fold more potent than the S-(+) enantiomer.

Racemate and S-enantiomer also available.

化合物库 for (R)-(-)-Rolipram

(R)-(-)-Rolipram is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for (R)-(-)-Rolipram

分子量 275.35
公式 C16H21NO3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 85416-75-7
PubChem ID 448055
InChI Key HJORMJIFDVBMOB-LBPRGKRZSA-N
Smiles O=C1NC[C@@H](C2=CC(OC3CCCC3)=C(OC)C=C2)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R)-(-)-Rolipram

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 27.54 100
DMSO 27.54 100

制备储备液 for (R)-(-)-Rolipram

以下数据基于产品分子量 275.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for (R)-(-)-Rolipram

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for (R)-(-)-Rolipram

参考文献是支持产品生物活性的出版物。

Ohsawa et al (1998) Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 77 147 PMID: 9681571

Owens et al (1997) Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 326 53 PMID: 9337850

Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127 105 PMID: 3019721

If you know of a relevant reference for (R)-(-)-Rolipram, please let us know.

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关键词: (R)-(-)-Rolipram, (R)-(-)-Rolipram supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, 1349, Tocris Bioscience

1 篇 (R)-(-)-Rolipram 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R)-(-)-Rolipram 的部分引用包括：

Boomkamp et al (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. Br J Pharmacol 171 2385 PMID: 24467222

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