主页 / 药理学 / Ion Channels / Potassium Channels / Calcium-Activated Potassium (KCa) Channels / Calcium-Activated Potassium (KCa) Channel Modulators / RA 2

RA 2

Cat. No. 7129 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent negative modulator of KCa2.3 and KCa3.1 channels
化学名： 1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate)
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RA 2

RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.

化合物库 for RA 2

RA 2 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for RA 2

分子量 414.36
公式 C22H16F2O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1867107-62-7
InChI Key XOZKRECPKXTNAK-UHFFFAOYSA-N
Smiles OC1=C(C=C(C(OCC2=CC(COC(C3=CC(F)=C(C=C3)O)=O)=CC=C2)=O)C=C1)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RA 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.44 100
ethanol 41.44 100

制备储备液 for RA 2

以下数据基于产品分子量 414.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.07 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for RA 2

参考文献是支持产品生物活性的出版物。

Olivan-Viguera et al (2015) A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol.Pharmacol. 338 PMID: 25468883

Olivan-Viguera et al (2016) Vascular reactivity profile of novel KCa3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 119 184 PMID: 26821335

If you know of a relevant reference for RA 2, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Calcium-Activated Potassium (KCa) Channel Modulators

关键词: RA 2, RA 2 supplier, RA-2, negative, gating, modulator, KCa, 3.1, 2.3, Ik, SK, calcium, sensitive, activated, potassium, channels, Ca2+-Activated, Potassium, Channels, 7129, Tocris Bioscience

篇 RA 2 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 RA 2 的引用文献。 您是否知道使用了 Tocris RA 2 的优秀论文？ 请告知我们.

RA 2 的评论

目前没有该产品的评论。 Be the first to review RA 2 and earn rewards!

Have you used RA 2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review