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说明： Potent and selective postitive allosteric modulator of GABAB receptors
化学名： 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
纯度： ≥98% (HPLC)
生物活性 for rac BHFF
rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.
化合物库 for rac BHFF
rac BHFF is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for rac BHFF
| 分子量 | 330.34 |
| 公式 | C17H21F3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 123557-91-5 |
| PubChem ID | 4332683 |
| InChI Key | RVNOANDLZIIFHB-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=C2C(C(O)(C(F)(F)F)C(O2)=O)=CC(C(C)(C)C)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for rac BHFF
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.03 | 100 | |
| ethanol | 33.03 | 100 |
制备储备液 for rac BHFF
以下数据基于产品分子量 330.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.03 mL | 15.14 mL | 30.27 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.05 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.03 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.61 mL |
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产品说明书 for rac BHFF
参考文献 for rac BHFF
参考文献是支持产品生物活性的出版物。
Malherbe et al (2008) Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br.J.Pharmacol. 154 797 PMID: 18536733
Koek et al (2013) Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse. J.Pharmacol.Exp.Ther. 344 553 PMID: 23275067
If you know of a relevant reference for rac BHFF, please let us know.
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关键词: rac BHFF, rac BHFF supplier, Potent, selective, GABAB, positive, allosteric, modulators, Receptors, 3313, Tocris Bioscience
1 篇 rac BHFF 的引用文献
引用文献是使用了 Tocris 产品的出版物。 rac BHFF 的部分引用包括：
Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Clin Exp Dermatol 5 10468 PMID: 26020477
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.