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Submit ReviewRaclopride
说明： Potent and selective D2 and D3 antagonist
化学名： 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide
纯度： ≥98% (HPLC)
生物活性 for Raclopride
Raclopride is a selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.
化合物库 for Raclopride
Raclopride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Raclopride
| 分子量 | 347.24 |
| 公式 | C15H20Cl2N2O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 84225-95-6 |
| PubChem ID | 3033769 |
| InChI Key | WAOQONBSWFLFPE-VIFPVBQESA-N |
| Smiles | ClC1=C(OC)C(C(NC[C@H]2N(CC)CCC2)=O)=C(O)C(Cl)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Raclopride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.72 | 100 | |
| ethanol | 8.68 | 25 |
制备储备液 for Raclopride
以下数据基于产品分子量 347.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.88 mL | 14.4 mL | 28.8 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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产品说明书 for Raclopride
参考文献 for Raclopride
参考文献是支持产品生物活性的出版物。
Hall et al (1989) Animal pharmacology of raclopride, a selective DA D2 antagonist. Psychopharmacol.Ser. 7 123 PMID: 2687851
Ogren et al (1986) The selective DA D2 receptor antagonist raclopride discriminates between DA-mediated motor functions. Psychopharmacology 90 287 PMID: 2947255
Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991
If you know of a relevant reference for Raclopride, please let us know.
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关键词: Raclopride, Raclopride supplier, Potent, selective, D2/D3, antagonists, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, Non-selective, 1810, Tocris Bioscience
12 篇 Raclopride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Raclopride 的部分引用包括：
Scardochio et al (2015) The Effects of Electrical and Optical Stimulation of Midbrain DArgic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Front Behav Neurosci 9 331 PMID: 26696851
Liu et al (2008) Increased DA level enhances male-male courtship in Drosophila. Int J Neuropsychopharmacol 28 5539 PMID: 18495888
Zheng et al (2014) Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. J Neurosci 306 R138 PMID: 24305061
Guo (2017) DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell 16 1323 PMID: 28975698
Ahmadiantehrani and Ron (2013) DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem PMID: 23373701
Huang et al (2009) Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology 34 1979 PMID: 19212317
Ogata et al (2012) DA and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells. J Comp Neurol 520 4032 PMID: 22678972
Verharen et al (2019) Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making. Neuropsychopharmacology 44 2195 PMID: 31254972
Lassus et al (2018) Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips. Sci Rep 8 17461 PMID: 30498197
Jiang et al (2015) SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway. Psychopharmacology (Berl) 18 PMID: 25522427
Heath et al (2015) Motivational assessment of mice using the touchscreen operant testing system: effects of DArgic drugs. Psychopharmacology (Berl) 232 4043 PMID: 26156636
Chiodi et al (2014) Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology 39 569 PMID: 23989619
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Raclopride 的评论
平均评分: 5 (Based on 1 Review.)
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Works as intended.
By
Anonymous on 05/14/2019
分析类型： In Vivo
种属： Mouse
Used at a range of doses to block dopamine D2 receptors in vivo to test effect on alcohol-cue learning and seeking behavior. Drug performed well and although didn't impact place preference it did have a clear effect in that it dose-dependently decrease locomotor activity.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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