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Radicicol

Cat. No. 1589 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Hsp90 inhibitor. Antifungal antibiotic
化学名： (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Radicicol

Radicicol is an antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.

技术数据 for Radicicol

分子量 364.78
公式 C18H17ClO6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 12772-57-5
PubChem ID 6323491
InChI Key WYZWZEOGROVVHK-GTMNPGAYSA-N
Smiles O=C2/C=C/C=C\[C@@H](O3)[C@H]3C[C@@H](C)OC(C1=C(O)C=C(O)C(Cl)=C1C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Radicicol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 3.65 10

制备储备液 for Radicicol

以下数据基于产品分子量 364.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 27.41 mL 137.07 mL 274.14 mL
0.5 mM 5.48 mL 27.41 mL 54.83 mL
1 mM 2.74 mL 13.71 mL 27.41 mL
5 mM 0.55 mL 2.74 mL 5.48 mL

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产品说明书 for Radicicol

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Radicicol

参考文献是支持产品生物活性的出版物。

Lee et al (2002) Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol.Cell.Endocrinol. 188 47 PMID: 11911945

Oikawa et al (1993) Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur.J.Pharmacol. 241 221 PMID: 7694864

Schulte et al (1999) Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol.Endocrinol. 13 1435 PMID: 10478836

If you know of a relevant reference for Radicicol, please let us know.

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关键词: Radicicol, Radicicol supplier, Hsp90, inhibitors, inhibits, Antifungal, antibiotics, Heat, Shock, Proteins, 90, Antibiotics, Antifungals, 1589, Tocris Bioscience

2 篇 Radicicol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Radicicol 的部分引用包括：

Stecklein et al (2012) BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation. Proc Natl Acad Sci U S A 109 13650 PMID: 22869732

Ginzberg et al (2018) Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity. Elife 7 PMID: 29889021

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