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Raphin 1

Cat. No. 6760 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6760 has been discontinued.

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说明： Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant
化学名： (2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Raphin 1

Raphin 1 is an inhibitor of the regulatory subunit PPP1R15B of protein phosphatase (Kd = 33 nM). Displays >30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesis in vitro. Induces transient reduction in protein synthesis in brains of wild type mice after single dose. Decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in a mouse model of Huntington's disease. Orally bioavailable and brain penetrant.

化合物库 for Raphin 1

Raphin 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Raphin 1

分子量 231.08
公式 C8H8Cl2N4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2022961-17-5
PubChem ID 5356739
InChI Key WLTSTDGGFCQWTK-PQMHYQBVSA-N
Smiles NC(N/N=C/C1=C(C(Cl)=CC=C1)Cl)=N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Raphin 1

参考文献是支持产品生物活性的出版物。

Krzyzosiak et al (2018) Target-based discovery of an inhibitor of the regulatory phosphatase PPP1R15B. Cell. 174 1216 PMID: 30057111

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关键词: Raphin 1, Raphin 1 supplier, Raphin1, protein, phosphatase, 1, regulatory, subunit, 15B, inhibitors, inhibits, synthesis, PPP1R15B, huntingtin, Protein, Ser/Thr, Phosphatases, 6760, Tocris Bioscience

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