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Raphin 1

Cat. No. 6760 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant
化学名： (2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Raphin 1

Raphin 1 is an inhibitor of the regulatory subunit PPP1R15B of protein phosphatase (Kd = 33 nM). Displays >30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesis in vitro. Induces transient reduction in protein synthesis in brains of wild type mice after single dose. Decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in a mouse model of Huntington's disease. Orally bioavailable and brain penetrant.

化合物库 for Raphin 1

Raphin 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Raphin 1

分子量 231.08
公式 C8H8Cl2N4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2022961-17-5
PubChem ID 5356739
InChI Key WLTSTDGGFCQWTK-PQMHYQBVSA-N
Smiles NC(N/N=C/C1=C(C(Cl)=CC=C1)Cl)=N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Raphin 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.11 100
ethanol 11.55 50

制备储备液 for Raphin 1

以下数据基于产品分子量 231.08。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.33 mL 21.64 mL 43.28 mL
5 mM 0.87 mL 4.33 mL 8.66 mL
10 mM 0.43 mL 2.16 mL 4.33 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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参考文献 for Raphin 1

参考文献是支持产品生物活性的出版物。

Krzyzosiak et al (2018) Target-based discovery of an inhibitor of the regulatory phosphatase PPP1R15B. Cell. 174 1216 PMID: 30057111

If you know of a relevant reference for Raphin 1, please let us know.

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关键词: Raphin 1, Raphin 1 supplier, Raphin1, protein, phosphatase, 1, regulatory, subunit, 15B, inhibitors, inhibits, synthesis, PPP1R15B, huntingtin, Protein, Ser/Thr, Phosphatases, 6760, Tocris Bioscience

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