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说明： FOXM1 inhibitor
化学名： 2-[[2-Oxo-2-(2-thienyl)ethyl]thio]-4,6-di-2-thienyl-3-pyridinecarbonitrile
纯度： ≥98% (HPLC)
生物活性 for RCM 1
RCM 1 is a forkhead box M1 (FOXM1) transcription factor inhibitor (IC50 = 0.72 μM). Inhibits expression of FOXM1 target genes. Induces FOXM1 protein degradation in vitro. Reduces airway resistance, increases lung compliance and decreases proinflammatory cytokine production in allergen-exposed mice.
技术数据 for RCM 1
| 分子量 | 424.58 |
| 公式 | C20H12N2OS4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 339163-65-4 |
| PubChem ID | 4273985 |
| InChI Key | DCCYTKKDAZEVLY-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC=CS1)CSC2=C(C(C3=CC=CS3)=CC(C4=CC=CS4)=N2)C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for RCM 1
参考文献 for RCM 1
参考文献是支持产品生物活性的出版物。
Sun et al (2017) The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci.Signal. 10 eaai8583 PMID: 28420758
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关键词: RCM 1, RCM 1 supplier, RCM1, forkhead, box, m1, FOXM1, transcription, factor, inhibitors, inhibits, allergy, cytokine, production, goblet, cells, anti-inflammatory, anti-asthma, Other, Transcription, Factors, 6845, Tocris Bioscience
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